|
KMID : 0380620190510050466
|
|
Korean Journal of Food Science and Technology
2019 Volume.51 No. 5 p.466 ~ p.472
|
|
|
Beneficial effect of collagen hydrolysate containing collagen tripeptides on ultraviolet B-induced skin photoaging
|
|
Kim Ae-Hyang
Ha Min-Woo
Kim Jun-Il
Piao Zhe
Shin Yong-Chul
Shin Dae-Keun
|
|
|
Abstract
|
|
|
|
This study was conducted to investigate anti-photoaging effects of collagen hydrolysate containing collagen tripeptides (CTP) in both HaCaT cells and SKH-1 hairless mice. CTP treatment was nontoxic to HaCaT cells and improved expression of biomarkers associated with aging of skin, such as, collagen 1A, metalloproteinase (MMP)-1, and MMP-13 after subjecting mice to ultraviolet B (UVB) irradiation. In animal studies, the depth and width of wrinkles in the skin of mice were determined upon subjecting them to UVB irradiation. However, positive effects on wrinkles on the skin of mice were seen following CTP supplementation. Collagen content and density of mouse skin were restored following CTP supplementation for 14 weeks after UVB irradiation. These results were based on the effects of CTP on protein levels of collagen 1A, MMP-1, and MMP-13. Therefore, CTP might have positive effects on the number, depth, and width of wrinkles caused by UVB irradiation in SKH-1 hairless mice.
|
|
|
KEYWORD
|
|
|
collagen tripeptides, collagen hydrolysate, anti-photoaging, ultraviolet B, skin wrinkle
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|